Review

Vol. 32 No. 9 (2021): 2021.32.9-Turkish Journal of Gastroenterology

Recommendations for Hepatitis B Immunoglobulin and Antiviral Prophylaxis Against Hepatitis B Recurrence After Liver Transplantation

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Genco Gencdal
Zeki Karasu
Ramazan Idilman
Murat Kiyici
Sedat Karademir
Gokhan Kabacam
Murat Harputluoglu 0
Merve Gurakar
Elif Sertesen
Hale Gokcan
Mesut Akarsu
Murat Dayangac
Nilay Danis
Yasemin Balaban
Murat Aladag
Murat Akyildiz
Meral Akdogan
Gupse Adali
Ilker Turan
Soner Onem

Abstract

The combination of hepatitis B immunoglobulin and potent nucleos(t)ide analogs after liver transplantation is considered as the standard of care for prophylaxis against hepatitis B virus recurrence. However, the recommended doses, route of administration, and duration of HBIG administration remain unclear. Moreover, hepatitis B immunoglobulin-free prophylaxis with potent nucleos(t)ide analogs has shown promising disease outcomes in preventing hepatitis B virus recurrence. The current recommendations, produced by the Turkish Association for the Study of the Liver, Acute Liver Failure and Liver Transplantation Special Interest Group, suggest a reduced need for hepatitis B immunoglobulin administration with effective long-term suppression of hepatitis B virus replication using potent nucleos(t) ide analogs after liver transplantation.<br>
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Cite this article as: Akarsu M, Onem S, Turan I, et al. Recommendations for hepatitis B immunoglobulin and antiviral prophylaxis against hepatitis B recurrence after liver transplantation. Turk J Gastroenterol. 2021; 32(9): 712-719.

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